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Saturday, December 16, 2006

NEARLY 200 MUTATED GENES HELP TUMOURS EMERGE, GROW AND SPREAD


New research has found the secret to the ‘gene code’ of breast and colon cancers. The discovery makes it possible for fresh hopes to be placed on new and effective treatments. The report:

[Last Updated: Saturday, 28 October 2006, 22:23 GMT 23:23 UK

Experts crack cancer 'gene codes'

US scientists have cracked the entire genetic code of breast and colon cancers, offering new treatment hopes.

The genetic map shows that nearly 200 mutated genes, most previously unknown, help tumours emerge, grow and spread.

The discovery could also lead to better ways to diagnose cancer in its early, most treatable stages, and personalised treatments, Science magazine reports.

The Johns Hopkins Kimmel Cancer Center says the findings suggest cancer is more complex than experts had believed.

Distinct differences

The mutated genes in breast and colon cancers were almost completely distinct, suggesting very different pathways for the development of each of these cancer types.

Each individual tumour appeared to have a different genetic blueprint, which could explain why cancers can behave very differently from person to person, the scientists said.

"No two patients are identical," co-author Dr Victor Velculescu explained.

Now researchers will study how these mutations occur in breast and colon cancers.

Previous cancer gene discoveries have already led to successful detection and treatment strategies.

For example, the breast cancer drug Herceptin targets a breast cancer cell receptor made by the Her2-neu gene. Blood tests for hereditary bowel cancer are based on the APC gene.

Personalised therapies

Dr Anna Barker, of the National Cancer Institute, said: "Maximising the numbers of targets available for drug development in a specific cancer means that patients will ultimately receive more personalised, less toxic therapies."

Ed Yong, of Cancer Research UK, commented: "This is potentially a very important piece of research.

"Most of the cancer genes identified in this study have not been previously linked to cancer.

"These newly identified genes could provide rich hunting grounds for scientists looking for new ways of treating or detecting cancers.

"In the future, scientists hope to be able to tailor plans for preventing or treating cancer to each person's individual genetic profile. Studies like this can help us to accomplish this goal."]

SOURCE: http://news.bbc.co.uk/2/hi/health/5325206.stm





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Greenville, Rhode Island bakery owned by the Cavanagh family, which uses the plant to produce church communion bread from just water and bread. That business is known to produce about 850 million sacramental wafers annually and to supply 80% of the Holy Communion bread used in American, Australian, Canadian, and British churches. The only middlemen in the supply chain are nuns living in convents! Now they want to expand to West Africa with their Christian sacramental ware for Pentecostal, Catholic, 'New Wave', and Orthodox church offerings. I make reference to the so-called New Wave churches - my term for those churches that broke away from the orthodoxy of the Protestant fold, just as the latter roke off from the Catholic church by virtue of the exploits of Martin Luther centuries ago. Many new-wave and other church goers in the generally undeveloped West African subregion of Africa pay more to religious organizations in monthly tithes and offerings than they do to their government in personal income and value added taxes. Now, that last fact is quite interesting because it is an admission that a bakery in Rhode Island has seen a huge market in the center of Black Africa for small white perfectly laminated and non-crumbly holy wheat bread, reportedly costing "less than a penny" apiece, for the use of both the bible-reading and the bible-believing religious organizations. However, the picture from the Cavanagh's factory floor speaks volumes, in my own opinion, about the need for the company to watch its business ethics and to treat all customers equally irrespective of location, creed, or other discriminatory demographic information or criteria. So, I just hope and pray that the wafers falling off the conveyor belt and by the way side are not destined for West Africa and that the actual wafers delivered will be wheat bread and water, and not just glutamate-free bread and 'pure' water, if you get my point, even if so requested by some shady, greedy, and unethical businessmen over in West Africa. Posted by Okonkwo O. Awa on Sunday, December 28, 2008.

In the summer of 2007, Pope Benedict XVI (BXVI) encouraged The Church to reach out to young people using new technologies, as he himself learned to send out cellphone text messages to the faithful. So in obedience, a tech savvy evangelizing Catholic priest got some help from a Web designer in order to write all the daily books of prayers into a low-cost computer software application downloadable onto the iPhone. Rev. Paolo Padrini's iTunes prayer book was officially approved by The Vatican's Pontifical Council for Social Communications in December 2008. Of course, all proceeds from the electronic prayer book venture will go to charity. Speaking of charitable behavior, The Holy See has seen it fit after 400 years to honor Galileo Galilei in 2009 as the "patron" of the non-mutual exclusivity of the faith versus reason dichotomy. That is very appropriate in this age of new technology, even though The Church still smarts from its error of judgment in calling the famous astronomer a heretic after he publicly embarrassed The Church by reporting that his scientific observations in Astronomy with his unique telescope had led him inexorably to believe that the Earth actually revolved around the sun, in direct opposition to the teaching of The Church at the time that Planet Earth was the center of the universe. In seeking to paint the Church in a new light of worldly knowledge by distancing itself from a past of imbibing pure dogma, The Vatican may have ventured to cross the final frontier and boundary between Science and Christianity by acknowledging recently that there could be life on planets other than the Earth! Posted by O. O. Awa on Wednesday, December 24, 2008.
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